SALAVATI LAB
PUBLICATIONS
– – – – – – 2024 – – – – – –
Rostamighadi M., Kamelshahroudi A., Pitsitikas V., Jacobson K., Salavati R. (2024) A pilot-scale screening of clinically approved drugs to identify uridine insertion/deletion RNA editing inhibitors in Trypanosoma brucei. ACS Infect. Dis.
Zamani H., Poorinmohammad N., Azimi A., Salavati R. (2024) From a bimodal to a multi-stage view on trypanosomes’ differential RNA editing. Trends Parasitol.
Poorinmohammad N., Salavati R. (2024) Prioritization of Trypanosoma brucei editosome protein interactions interfaces at residue resolution through proteome-scale network analysis. BMC Mol. Biol.
Mirzavand P, Salavati R. (2024) Functional domain annotation by structural similarity. NAR Genom Bioinform.
– – – – – – 2023 – – – – – –
Smoniewski CM., Borujeni PM., Hampton M., Petersen A., Faacks S., Salavati R., Zimmer S. (2023) Manipulation of mitochondrial poly(A) polymerase family proteins in Trypanosoma brucei impacts mRNA termini processing. Front. Parasitol.
Rostamighadi M., Kamelshahroudi A., Mehta V., Zeng FY., Pass I., Chung T., Salavati R. (2023) High-throughput Screening of
Compounds Targeting RNA Editing in Trypanosoma brucei: Novel Molecular Scaffolds with Broad Trypanocidal Effects
Biochem. Pharmacol.
Ehlert C., Poorinmohammad N., Mohammaei S., Zhang L., Salavati R. (2023) Structure-function analysis of RBP7910: an editosome Z-binding protein in trypanosomatids Molecules
Smoniewski CM., Borujeni PM., Petersen A., Hampton M., Salavati R., Zimmer S. (2023) Circular mitochondrial-encoded mRNAs are a distinct subpopulation of mitochondrial mRNA in Trypanosoma brucei. Sci Rep.
Mirzavand P, Salavati R. (2023). Functional domain annotation by structural similarity.
https://www.biorxiv.org/content/10.1101/2023.01.18.524644v2
– – – – – – 2022 – – – – – –
Rostamighadi M , Mehta V., Khan RH, Moses D., Salavati R. (2022) Hammerhead ribozyme-based U-insertion and deletion RNA editing assays for multiplexing in HTS applications. RNA.
Moses D., Mehta V., Salavati R. (2022). The discovery and characterization of two novel structural motifs on the C-terminal domain of kinetoplastid RNA editing ligases. RNA.
– – – – – – 2020 – – – – – –
Aphasizheva I., Alfonzo J., Carnes J., Cestari I., Goringer U., Stephen H., Lukes J., Madison-Antenuccii S., Maslov D., McDermott S., Ochsenreiter T., Read L., Salavati R., Schnaufer A., Schneider A., Simpson L., Stuart K., Yurchenko V., Zhou Z., Zikova A., Zhang L., Ziimmer S., Aphasizhev R. (2020). Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.
Trends in Parasitology 36(4): 337-355
Mehta V., Moshiri H., Srikanth A., Kala S., Lukeš J., Salavati R. (2020). Sulfonated inhibitors of the RNA editing ligases validate the essential role of the MRP1/2 proteins in kinetoplastid RNA editing. RNA. 26(7): 827-835
– – – – – – 2019 – – – – – –
Nikpour N., Salavati R. (2019). The RNA binding activity of the first identified trypanosome protein with Z-DNA-binding domains.
Sci Rep. 9(1): 5904
Salavati R., Gazestani VH. (20198). Gene Function Discovery for Kinetoplastid Pathogens. Trends Parasitol. 35(1): 8-12
– – – – – – 2018 – – – – – –
Gazestani VH., Hampton M., Shaw AK., Salavati R., Zimmer SL. (2018). Tail characteristics of Trypanosoma brucei mitochondrial transcripts are developmentally altered in a transcript-specific manner. Int J Parasitol. 48(2): 179-189
– – – – – – 2017 – – – – – –
Gazestani VH., Yip CW., Nikpour N., Berghuis N., Salavati R. (2017). TrypsNetDB: an integrated framework for the functional characterization of trypanosomatid proteins. PLoS Negl Trop Dis. 11(2): e0005368
Kala S., Mehta V., Yip CW., Moshiri H., Najafabadi HS., Ma R., Nikpour N., Zimmer SL., Salavati R. (2017). The interaction of a Trypanosoma brucei KH-domain protein with a ribonuclease is implicated in ribosome processing.
Mol Bioiochem Parasitol. 211: 94-103
– – – – – – 2016 – – – – – –
Gazestani VH., Hampton M., Abrahante JE., Salavati R.*, Zimmer SL*. (2016). circTAIL-seq, a targeted method for deep analysis of RNA 3' tails, reveals transcript-specific differences by multiple metrics. *(Co-corresponding authors). RNA. 22(3): 477-486
Shaneh As., Purisima E.O., Salavati R., Sulea T. (2016). Structural studies of Trypanosoma brucei RNA editing ligases and their binding partner proteinss. Biochemistry. 55(16): 2319-2331
Gazestani VH, Nikpour N., Mehta V., Najafabadi H.S., Moshiri H, Jardim A., Salavati R. (2016). A Protein Complex Map of Trypanosoma brucei. PLos Negl. Trop. Dis. 10(3): e0004533
– – – – – – 2015 – – – – – –
Gazestani VH., Salavati R. (2015). Deciphering RNA Regulatory Elements Involved in the Developmental and Environmental Gene Regulation of Trypanosoma brucei. PLoS One. 10(11): e0142342
Bhaskar J., Gazestani VH., Yip CW., Salavati R. (2015). The DRBD13 RNA binding protein is involved in the insect-stage differentiation process of Trypanosoma brucei. FEBS Letters. 589(15): 1966-1974
Mehta V., Sen R., Moshiri H., Salavati R. (2015). Mutational Analysis of Trypanosoma brucei RNA Editing Ligase Reveals Regions Critical for Interaction with KREPA2. PLoS One. 10(3): e0120844
Moshiri H., Mehta V., Yipp CW., Salavati R. (2015). Pilot-Scale compound screening against RNA editing identifies
Trypanocidal agents. J Biomol Screen. 20(1): 92–100
– – – – – – 2014 – – – – – –
Moshiri H., Mehta V., Salavati R. (2014). RNA catalyst as a reporter for screening drugs against RNA editing in trypanosomes.
J. Vis. Exp. (89), e51712
Gazestani VH., Lu Z., Salavati R. (2014). Deciphering RNA regulatory elements in trypanosomatids: one piece at a time
or genome-wide? Trends Parasitol. 30(5): 234-240
– – – – – – 2013 – – – – – –
Najafabadi HS., Lu Z., Macpherson C., Mehta V., Adoue V., Pastinen T., Salavati R. (2013). Global identification of
conserved post-transcriptional regulatory programs in trypanosomatids. Nucleic Acids Res. 41(18): 8591-8600
– – – – – – 2012 – – – – – –
Kala S., Moshiri H., Mehta V., Yip CW., Salavati R. (2012). The oligonucleotide binding (OB)-fold domain of KREPA4 is essential for stable incorporation into editosomes. PLoS One. 7(10): e46864
Goodarzi H., Najafabadi HS., Oikonomou P., Greco TM., Fish L., Salavati R., Cristea IM., Tavazoie S. (2012). Systematic discovery of structural elements governing stability of mammalian messenger RNAs. Nature. 485(7397): 264-268
Salavati R., Moshiri H., Kala S., Najafabadi HS. (2012). Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogens. Int J Parasitol Drugs Drug Resist. 2: 36-46
– – – – – – 2011 – – – – – –
Moshiri H., Acoca S., Kala S., Najafabadi HS., Hogues H., Purisima E., Salavati R. (2011). Naphthalene-based RNA editing inhibitor blocks RNA editing activities and editosome assembly in Trypanosoma brucei. J Biol Chem. 286(16): 14178-14189
– – – – – – 2010 – – – – – –
Najafabadi HS., Salavati R. (2010). Functional genome annotation by combined analysis across microarray studies of Trypanosoma brucei. PLoS Negl Trop Dis. 4(8): e810
Kala S., Salavati R. (2010). OB-fold domain of KREPA4 mediates high affinity interaction with guide RNA and also possesses
annealing activity. RNA. 16(10): 1951-1967
Moshiri H., Salavati R. (2010). A fluorescence-based reporter substrate for monitoring RNA editing in trypanosomatid pathogens.
Nucleic Acids Res. 38(13): e138
Salavati R., Najafabadi HS. (2010). Sequence-based functional annotation: what if most of the genes are unique to a genome?
Trends Parasitol. 26(5): 225-229
– – – – – – 2009 – – – – – –
Najafabadi HS., Goodarzi H., Salavati R. (2009). Universal function-specificity of codon usage.
Nucleic Acids Res. 37(21): 7014-7023
Mao Y., Najafabadi HS., Salavati R. (2009). Genome-wide computational identification of functional RNA
elements in Trypanosoma brucei. BMC Genomics. 10: 355
Shaneh A., Salavati R. (2009). Kinetoplastid RNA editing ligases 1 and 2 exhibit different electrostatic properties.
J Mol Model. 16(1): 61-76
– – – – – – 2008 – – – – – –
Najafabadi HS., Salavati R. (2008). Sequence-based prediction of protein-protein interactions by means of codon usage.
Genome Biol. 9(5): R87
– – – – – – 2006 – – – – – –
Mian IS., Worthey EA., Salavati R. (2006). Taking U out, with two nucleases? BMC Bioinformatics. 7: 305
Panigrahi AK., Ernst NL., Domingo GJ., Fleck M., Salavati R., Stuart KD. (2006). Compositionally and functionally distinct editosomes in Trypanosoma brucei. RNA. 12(6): 1038-1049
Salavati R., Ernst NL., O'Rear J., Gilliam T., Tarun S Jr., Stuart KD. (2006). KREPA4, an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA. 12(5): 819-831
– – – – – – 2004 – – – – – –
Deng J., Schnaufer A., Salavati R., Stuart KD., Hol WG. (2004). High resolution crystal structure of a key editosome enzyme from Trypanosoma brucei: RNA editing ligase 1. J Mol Biol. 343(3): 601-613
– – – – – – 2003 – – – – – –
Worthey EA., Schnaufer A., Mian IS., Stuart K., Salavati R. (2003). Comparative analysis of editosome proteins in trypanosomatids.
Nucleic Acids Res. 31(22): 6392-6408
Schnaufer A., Ernst NL., Palazzo SS., O'Rear J., Salavati R., Stuart K. (2003). Separate insertion and deletion
subcomplexes of the Trypanosoma brucei RNA editing complex. Mol Cell. 12(2): 307-319
Ernst NL., Panicucci B., Igo RP Jr., Panigrahi AK., Salavati R., Stuart K. (2003). TbMP57 is a 3' terminal uridylyl transferase
(TUTase) of the Trypanosoma brucei editosome. Mol Cell. 11(6): 1525-1536
Worthey EA., Martinez-Calvillo S., Schnaufer A., Aggarwal G., Cawthra J., Fazelinia G., Fong C., Fu G., Hassebrock M.,
Hixson G., Ivens AC., Kiser P., Marsolini F., Rickel E., Salavati R., Sisk E., Sunkin SM., Stuart KD., Myler PJ. (2003).
Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene.
Nucleic Acids Res. 31(14): 4201-4210
Wang B., Ernst NL., Palazzo SS., Panigrahi AK., Salavati R., Stuart K. (2003). TbMP44 is essential for RNA editing and
structural integrity of the editosome in Trypanosoma brucei. Eukaryot Cell. 2(3): 578-587
Domingo GJ., Palazzo SS., Wang B., Pannicucci B., Salavati R., Stuart KD. (2003). Dyskinetoplastic Trypanosoma
brucei contains functional editing complexes. Eukaryot Cell. 2(3): 569-577
Palazzo SS., Panigrahi AK., Igo RP., Salavati R., Stuart KD. (2003). Kinetoplastid RNA editing ligases: complex association, characterization, and substrate requirements. Mol Biochem Parasitol. 127(2): 161-167
Panigrahi AK., Schnaufer A., Ernst NL., Wang B., Carmean N., Salavati R., Stuart KD. (2003). Identification of novel components of Trypanosoma brucei editosomes. RNA. 9(4): 484-492
– – – – – – 2002 – – – – – –
Igo RP Jr., Weston DS., Ernst NL., Panigrahi AK., Salavati R., Stuart K. (2002). Role of uridylate-specific
exoribonuclease activity in Trypanosoma brucei RNA editing. Eukaryot Cell. 1(1): 112-118
Salavati R., Panigrahi AK., Morach BA., Palazzo SS., Igo RP., Stuart KD. (2002). Endoribonuclease activities of
Trypanosoma brucei mitochondria. Mol Biochem Parasitol. 120(1): 23-31
Drozdz M., Palazzo SS., Salavati R., O'Rear J., Clayton C., Stuart KD. (2002). TbMP81 is required for RNA
editing in Trypanosoma bruceis. EMBO J. 21(7): 1791-1799
Wang B., Salavati R., Heidmann S., Stuart KD. (2002). A hammerhead ribozyme substrate and reporter for
in vitro kinetoplastid RNA editing. RNA. 8(4): 548-554
– – – – – – 2022 – – – – – –
Rostamighadi M , Mehta V., Khan RH, Moses D., Salavati R. (2022) Hammerhead ribozyme-based U-insertion and deletion RNA editing assays for multiplexing in HTS applications. RNA.
Moses D., Mehta V., Salavati R. (2022). The discovery and characterization of two novel structural motifs on the C-terminal domain of kinetoplastid RNA editing ligases. RNA.
– – – – – – 2020 – – – – – –
Aphasizheva I., Alfonzo J., Carnes J., Cestari I., Goringer U., Stephen H., Lukes J., Madison-Antenuccii S., Maslov D., McDermott S., Ochsenreiter T., Read L., Salavati R., Schnaufer A., Schneider A., Simpson L., Stuart K., Yurchenko V., Zhou Z., Zikova A., Zhang L., Ziimmer S., Aphasizhev R. (2020). Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.
Trends in Parasitology 36(4): 337-355
Mehta V., Moshiri H., Srikanth A., Kala S., Lukeš J., Salavati R. (2020). Sulfonated inhibitors of the RNA editing ligases validate the essential role of the MRP1/2 proteins in kinetoplastid RNA editing. RNA. 26(7): 827-835
– – – – – – 2019 – – – – – –
Nikpour N., Salavati R. (2019). The RNA binding activity of the first identified trypanosome protein with Z-DNA-binding domains.
Sci Rep. 9(1): 5904
Salavati R., Gazestani VH. (20198). Gene Function Discovery for Kinetoplastid Pathogens. Trends Parasitol. 35(1): 8-12
– – – – – – 2018 – – – – – –
Gazestani VH., Hampton M., Shaw AK., Salavati R., Zimmer SL. (2018). Tail characteristics of Trypanosoma brucei mitochondrial transcripts are developmentally altered in a transcript-specific manner. Int J Parasitol. 48(2): 179-189
– – – – – – 2017 – – – – – –
Gazestani VH., Yip CW., Nikpour N., Berghuis N., Salavati R. (2017). TrypsNetDB: an integrated framework for the functional characterization of trypanosomatid proteins. PLoS Negl Trop Dis. 11(2): e0005368
Kala S., Mehta V., Yip CW., Moshiri H., Najafabadi HS., Ma R., Nikpour N., Zimmer SL., Salavati R. (2017). The interaction of a Trypanosoma brucei KH-domain protein with a ribonuclease is implicated in ribosome processing.
Mol Bioiochem Parasitol. 211: 94-103
– – – – – – 2016 – – – – – –
Gazestani VH., Hampton M., Abrahante JE., Salavati R.*, Zimmer SL*. (2016). circTAIL-seq, a targeted method for deep analysis of RNA 3' tails, reveals transcript-specific differences by multiple metrics. *(Co-corresponding authors). RNA. 22(3): 477-486
Shaneh As., Purisima E.O., Salavati R., Sulea T. (2016). Structural studies of Trypanosoma brucei RNA editing ligases and their binding partner proteinss. Biochemistry. 55(16): 2319-2331
Gazestani VH, Nikpour N., Mehta V., Najafabadi H.S., Moshiri H, Jardim A., Salavati R. (2016). A Protein Complex Map of Trypanosoma brucei. PLos Negl. Trop. Dis. 10(3): e0004533
– – – – – – 2015 – – – – – –
Gazestani VH., Salavati R. (2015). Deciphering RNA Regulatory Elements Involved in the Developmental and Environmental Gene Regulation of Trypanosoma brucei. PLoS One. 10(11): e0142342
Bhaskar J., Gazestani VH., Yip CW., Salavati R. (2015). The DRBD13 RNA binding protein is involved in the insect-stage differentiation process of Trypanosoma brucei. FEBS Letters. 589(15): 1966-1974
Mehta V., Sen R., Moshiri H., Salavati R. (2015). Mutational Analysis of Trypanosoma brucei RNA Editing Ligase Reveals Regions Critical for Interaction with KREPA2. PLoS One. 10(3): e0120844
Moshiri H., Mehta V., Yipp CW., Salavati R. (2015). Pilot-Scale compound screening against RNA editing identifies
Trypanocidal agents. J Biomol Screen. 20(1): 92–100
– – – – – – 2014 – – – – – –
Moshiri H., Mehta V., Salavati R. (2014). RNA catalyst as a reporter for screening drugs against RNA editing in trypanosomes.
J. Vis. Exp. (89), e51712
Gazestani VH., Lu Z., Salavati R. (2014). Deciphering RNA regulatory elements in trypanosomatids: one piece at a time
or genome-wide? Trends Parasitol. 30(5): 234-240
– – – – – – 2013 – – – – – –
Najafabadi HS., Lu Z., Macpherson C., Mehta V., Adoue V., Pastinen T., Salavati R. (2013). Global identification of
conserved post-transcriptional regulatory programs in trypanosomatids. Nucleic Acids Res. 41(18): 8591-8600
– – – – – – 2012 – – – – – –
Kala S., Moshiri H., Mehta V., Yip CW., Salavati R. (2012). The oligonucleotide binding (OB)-fold domain of KREPA4 is essential for stable incorporation into editosomes. PLoS One. 7(10): e46864
Goodarzi H., Najafabadi HS., Oikonomou P., Greco TM., Fish L., Salavati R., Cristea IM., Tavazoie S. (2012). Systematic discovery of structural elements governing stability of mammalian messenger RNAs. Nature. 485(7397): 264-268
Salavati R., Moshiri H., Kala S., Najafabadi HS. (2012). Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogens. Int J Parasitol Drugs Drug Resist. 2: 36-46
– – – – – – 2011 – – – – – –
Moshiri H., Acoca S., Kala S., Najafabadi HS., Hogues H., Purisima E., Salavati R. (2011). Naphthalene-based RNA editing inhibitor blocks RNA editing activities and editosome assembly in Trypanosoma brucei. J Biol Chem. 286(16): 14178-14189
– – – – – – 2010 – – – – – –
Najafabadi HS., Salavati R. (2010). Functional genome annotation by combined analysis across microarray studies of Trypanosoma brucei. PLoS Negl Trop Dis. 4(8): e810
Kala S., Salavati R. (2010). OB-fold domain of KREPA4 mediates high affinity interaction with guide RNA and also possesses
annealing activity. RNA. 16(10): 1951-1967
Moshiri H., Salavati R. (2010). A fluorescence-based reporter substrate for monitoring RNA editing in trypanosomatid pathogens.
Nucleic Acids Res. 38(13): e138
Salavati R., Najafabadi HS. (2010). Sequence-based functional annotation: what if most of the genes are unique to a genome?
Trends Parasitol. 26(5): 225-229
– – – – – – 2009 – – – – – –
Najafabadi HS., Goodarzi H., Salavati R. (2009). Universal function-specificity of codon usage.
Nucleic Acids Res. 37(21): 7014-7023
Mao Y., Najafabadi HS., Salavati R. (2009). Genome-wide computational identification of functional RNA
elements in Trypanosoma brucei. BMC Genomics. 10: 355
Shaneh A., Salavati R. (2009). Kinetoplastid RNA editing ligases 1 and 2 exhibit different electrostatic properties.
J Mol Model. 16(1): 61-76
– – – – – – 2008 – – – – – –
Najafabadi HS., Salavati R. (2008). Sequence-based prediction of protein-protein interactions by means of codon usage.
Genome Biol. 9(5): R87
– – – – – – 2006 – – – – – –
Mian IS., Worthey EA., Salavati R. (2006). Taking U out, with two nucleases? BMC Bioinformatics. 7: 305
Panigrahi AK., Ernst NL., Domingo GJ., Fleck M., Salavati R., Stuart KD. (2006). Compositionally and functionally distinct editosomes in Trypanosoma brucei. RNA. 12(6): 1038-1049
Salavati R., Ernst NL., O'Rear J., Gilliam T., Tarun S Jr., Stuart KD. (2006). KREPA4, an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA. 12(5): 819-831
– – – – – – 2004 – – – – – –
Deng J., Schnaufer A., Salavati R., Stuart KD., Hol WG. (2004). High resolution crystal structure of a key editosome enzyme from Trypanosoma brucei: RNA editing ligase 1. J Mol Biol. 343(3): 601-613
– – – – – – 2003 – – – – – –
Worthey EA., Schnaufer A., Mian IS., Stuart K., Salavati R. (2003). Comparative analysis of editosome proteins in trypanosomatids.
Nucleic Acids Res. 31(22): 6392-6408
Schnaufer A., Ernst NL., Palazzo SS., O'Rear J., Salavati R., Stuart K. (2003). Separate insertion and deletion
subcomplexes of the Trypanosoma brucei RNA editing complex. Mol Cell. 12(2): 307-319
Ernst NL., Panicucci B., Igo RP Jr., Panigrahi AK., Salavati R., Stuart K. (2003). TbMP57 is a 3' terminal uridylyl transferase
(TUTase) of the Trypanosoma brucei editosome. Mol Cell. 11(6): 1525-1536
Worthey EA., Martinez-Calvillo S., Schnaufer A., Aggarwal G., Cawthra J., Fazelinia G., Fong C., Fu G., Hassebrock M.,
Hixson G., Ivens AC., Kiser P., Marsolini F., Rickel E., Salavati R., Sisk E., Sunkin SM., Stuart KD., Myler PJ. (2003).
Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene.
Nucleic Acids Res. 31(14): 4201-4210
Wang B., Ernst NL., Palazzo SS., Panigrahi AK., Salavati R., Stuart K. (2003). TbMP44 is essential for RNA editing and
structural integrity of the editosome in Trypanosoma brucei. Eukaryot Cell. 2(3): 578-587
Domingo GJ., Palazzo SS., Wang B., Pannicucci B., Salavati R., Stuart KD. (2003). Dyskinetoplastic Trypanosoma
brucei contains functional editing complexes. Eukaryot Cell. 2(3): 569-577
Palazzo SS., Panigrahi AK., Igo RP., Salavati R., Stuart KD. (2003). Kinetoplastid RNA editing ligases: complex association, characterization, and substrate requirements. Mol Biochem Parasitol. 127(2): 161-167
Panigrahi AK., Schnaufer A., Ernst NL., Wang B., Carmean N., Salavati R., Stuart KD. (2003). Identification of novel components of Trypanosoma brucei editosomes. RNA. 9(4): 484-492
– – – – – – 2002 – – – – – –
Igo RP Jr., Weston DS., Ernst NL., Panigrahi AK., Salavati R., Stuart K. (2002). Role of uridylate-specific
exoribonuclease activity in Trypanosoma brucei RNA editing. Eukaryot Cell. 1(1): 112-118
Salavati R., Panigrahi AK., Morach BA., Palazzo SS., Igo RP., Stuart KD. (2002). Endoribonuclease activities of
Trypanosoma brucei mitochondria. Mol Biochem Parasitol. 120(1): 23-31
Drozdz M., Palazzo SS., Salavati R., O'Rear J., Clayton C., Stuart KD. (2002). TbMP81 is required for RNA
editing in Trypanosoma bruceis. EMBO J. 21(7): 1791-1799
Wang B., Salavati R., Heidmann S., Stuart KD. (2002). A hammerhead ribozyme substrate and reporter for
in vitro kinetoplastid RNA editing. RNA. 8(4): 548-554